Point-of-Care Autofluorescence Imaging for Real-Time Sampling and Treatment Guidance of Bioburden in Chronic Wounds: First-in-Human Results

Journal: PLOS ONE
Authors: Ralph S. DaCosta, Iris Kulbatski, Liis Lindvere-Teene, Danielle Starr, Kristina Blackmore, Jason I. Silver, Julie Opoku, Yichao Charlie Wu, Philip J. Medeiros, Wei Xu, Lizhen Xu, Brian C. Wilson, Cheryl Rosen, Ron Linden
Published Date: February 2015
Background:
Traditionally, chronic wound infection is diagnosed by visual inspection under white light and microbiological sampling, which are subjective and suboptimal, respectively, thereby delaying diagnosis and treatment. To address this, we developed a novel handheld, fluorescence imaging device (PRODIGI) that enables non-contact, real-time, high-resolution visualization and differentiation of key pathogenic bacteria through their endogenous autofluorescence, as well as connective tissues in wounds.
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