Abstract: New concepts and strategies for managing wound infection, biofilm and impaired wound healing are urgently needed. This study examines the effects of non-thermal gas plasma (NTGP) in the management of diabetic foot ulcers stalled by subclinical, biofilm-related wound infection. Patients either received local standard of care or standard care plus 5 minutes NTGP twice weekly. This included using the MolecuLight i:X to assess the presence and location of elevated bacteria (>104 CFU/g) in the wounds. Qualitative analysis of assessed parameters (wound closure, bioburden, inflammation) showed that overall outcomes were good to very good. The data obtained strengthens the evidence of the beneficial effect of NTGP on wound healing in patients with diabetic foot ulcers.
The efficacy of non-thermal gas plasma in the treatment of diabetic foot ulcers stalled by subclinical, biofilm-related wound infection
Cornelia Wiegand, Laura Rudkte, Keith Cutting, Jeiram Jeyaratnam, Mary McGovern, Paul Chadwick, Samantha Haycocks, David Russell, Nikki Dewhirst, Janet Woods, Steven Jeffery
Cornelia Wiegand is Head of Laboratory, Department of Dermatology, University Hospital Jena, Germany
Laura Rudtke is Medical PhD Student, Department of Dermatology, University Hospital Jena, Germany
Keith Cutting is Clinical Research Consultant, Health Directions, Hertfordshire, UK
Jeiram Jeyaratnam is Business Development Manager, Adtec Europe Ltd, Twickenham, UK
Mary McGovern is Managing Director, Adtec Europe Ltd, Twickenham, UK
Paul Chadwick is Clinical Director The Royal College of Podiatry and Visiting Professor Birmingham City University, Birmingham, UK
Samantha Haycocks is Research Nurse, Podiatry Department, Salford Royal NHS Foundation Trust, Salford, UK
David Russell is Associate Professor, Leeds Institute for Clinical Trials Research, University of Leeds and Honorary Consultant Vascular Surgeon, Diabetes Limb Salvage Service / Leeds Vascular Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Nikki Dewhirst is Senior Vascular Research Nurse, Diabetes Limb Salvage Service/Leeds Vascular Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Janet Woods is Vascular Research Nurse, Diabetes Limb Salvage Service / Leeds Vascular Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Steven Jeffery is Consultant Plastic Surgeon and Professor of wound study, Birmingham City University, Birmingham, UK
Wounds International, Vol 13 Issue 4 Dec. 2022
MolecuLight successfully used to detect location & load of elevated bacterial load prior to delivery of non-thermal gas plasma in DFU patients
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