Effectiveness of Alprep Pad® for cleaning and debridement of DFUs was studied
MolecuLight i:X was used to establish the presence of bioburden in the wound bed, wound edge and periwound skin
Wound size was measured using the MolecuLight device
Debridement/Wound Hygiene
MolecuLight used in clinical trial of sodium hypochlorite to test its efficacy in reducing bacterial burden and promoting healing
Used to assess the presence of elevated burden in patients pre- and post-treatment
Initial findings: Sodium hypochlorite is efficacious in reducing bacterial burden and promoting healing
Using novel debridement tool, fluorescence imaging demonstrated a reduction in bacterial load in 69% of cases, with complete resolution in 19% of wounds.
Advantage of utilizing point-of-care fluorescence imaging for improving bacterial detection and optimizing treatment strategies with wound sepsis in stage 4 pelvic pressure injuries.
UPPER and LOWER CSS checklists were developed to distinguish between local & systemic infection
Addition of fluorescence imaging led to more judicious application of antimicrobials & more thorough wound bed preparation
95% sensitivity when fluorescence imaging was added over signs and symptoms alone (p<0.01)
25% decrease in wound area over 4 weeks with the elimination of bacterial fluorescence from wounds
A positive healing trajectory was associated with the implementation of fluorescence imaging (i:X)
All wounds where fluorescence signal from bacteria was eradicated healed within 2-6 weeks
24% of VLU periwound area was colonized by high bacterial loads pre-debridement
99% reduction of bacterial signal in the wound bed after debridement using fluorescence guidance
36% of periwound bacterial signal is left behind after standard debridement in VLUs (without
the guidance of fluorescence)
Detection of Bacterial Burden
Hand trauma wounds were inspected for CSS and underwent fluorescence imaging for detection of bacterial burden
Fluorescence signals correlated with CSS and swab results in 97% of wounds
Fluorescence imaging can guide surgical debridement by providing real-time information on wounds' infected areas
This case series describes the utility of fluorescence imaging for detection of bacterial burden in an adult burn center
Fluorescence imaging informed decision making on dressings, antimicrobials and antibiotics used at point of care
Swabs confirmed accuracy of imaging results (positive or negative) in all 10 cases
>95% measurement accuracy of MolecuLight i:X device for wound area, length and width
89% of wounds with red or cyan fluorescence in the periwound, a region rarely sampled
85% of DFUs where additional debridement was performed based on fluorescence guidance
Detection of Bacterial Burden
Fluorescence imaging was used to monitor elevated bacterial loads during burn reconstruction
Weekly fluorescence imaging led to detection of elevated bacterial loads in the dermal template at the point-of-care
This resulted in debridement
This peer-reviewed tutorial describes how to interpret the various fluorescence signals detected from wound tissues and bacteria using the fluorescence imaging procedure
Methods to minimize imaging artifacts and misinterpretation are described
Detection of Bacterial Burden
The MolecuLight i:X aided clinicians in their management of wound infections
This was done through image informed debridement/treatment response monitoring to debridement & other wound therapies
Bacterial presence or absence based on fluorescence images correlated with swab results in all cases
Fluorescence images for identifying bacterial loads of concern was 100% vs 63% sensitivity of CSS
Fluorescence images for identifying bacterial loads of concern was 92% compared to 82% accuracy of CSS
Fluorescence correctly identified all 8 wounds that were positive for significant bacterial growth on cultures
Detection of Bacterial Burden
