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Evidence Category:
Pre-Clinical Applications

Pre-Clinical Applications

Successful removal of biofilm in wounds is contingent upon accurate detection of bacterial burden

Fluorescence imaging (MolecuLight i:X) can detect wound bacteria encased in biofilm, as confirmed by SEM and histopathology

Red fluorescence observed from in vivo polymicrobial wound models is specific to bacteria, and not from an immune response

Fluorescence imaging (MolecuLight i:X) can detect both planktonic & biofilm bacterial cultures

Biofilm is present in more than 70% of chronic wounds and it contributes to delayed healing

Using fluorescence imaging to localize bacteria may facilitate targeted disruption of biofilm & bacterial removal

A pre-clinical mouse wound model demonstrating the safety and feasibility of the fluorescence imaging procedure to visualize elevated bacterial burden in wounds

After treatment with antibiotics, bacterial fluorescence signal correlated with quantitative changes in wound bacterial load