Monitoring the Effectiveness of an Antibiotic Against MRSA with the MolecuLight i:X™


"I had tried numerous treatments targeting this patient’s MRSA, none of which were effective. The MolecuLight images demonstrated a reduction in bacteria after one week of antibiotic treatment."
- Rose Raizman RN-EC, MSc


Methicillin resistant Staphylococcus aureus (MRSA) infections are difficult to treat with standard types of antibiotics and are therefore more dangerous and more costly to the healthcare system.

Clinical Synopsis: Although Negative Pressure Wound Therapy (NPWT) had significantly reduced wound size in this non-healing venous leg ulcer, all treatments targeting MRSA infection had been unsuccessful. This prompted prescription of a newly available oral antibiotic. After one week of treatment, MolecuLight i:X fluorescence images revealed a significant decrease in bioburden, providing immediate feedback on antibiotic effectiveness.

Figure 1: Standard Imaging ModeTM.Figure 1: Standard Imaging ModeTM.
Figure 2: Fluorescence Imaging ModeTM. Presence of bacteria indicated by red color. Figure 2: Fluorescence Imaging ModeTM.
Presence of bacteria indicated by red color.
Figure 3: Standard Imaging ModeTM after one week of treatment. Figure 3:Standard Imaging ModeTM after one week of treatment.
Figure 4:Fluorescence Imaging ModeTM after one week of treatment. The noticeable decrease in red color suggests significant decrease in bacterial burden.Figure 4: Fluorescence Imaging ModeTM after one week of treatment. The noticeable decrease in red color suggests significant decrease in bacterial burden.

Patient Condition
50 year old male patient with a venous leg ulcer ( > 1 year) on left medial ankle. Wound presented with heavy drainage and a MRSA infection that had persisted over many months of care, despite numerous antibiotics and antimicrobials. Patient’s wound received regular cleaning and debridement and was being treated with negative pressure wound therapy.